Improved Doxorubicin Encapsulation and Pharmacokinetics of Ferritin-Fusion Protein Nanocarriers Bearing Proline, Serine, and Alanine Elements.

@article{Falvo2016ImprovedDE,
  title={Improved Doxorubicin Encapsulation and Pharmacokinetics of Ferritin-Fusion Protein Nanocarriers Bearing Proline, Serine, and Alanine Elements.},
  author={Elisabetta Falvo and Elisa Tremante and Alessandro Arcovito and Massimiliano Papi and N Caspi El’ad and Alberto Boffi and Veronica Morea and Giamaica Conti and Giuseppe Toffoli and Giulio Fracasso and Patrizio Giacomini and Pierpaolo Ceci},
  journal={Biomacromolecules},
  year={2016},
  volume={17 2},
  pages={
          514-22
        }
}
A novel human ferritin-based nanocarrier, composed of 24 modified monomers able to auto-assemble into a modified protein cage, was produced and used as selective carrier of anti-tumor payloads. Each modified monomer derives from the genetic fusion of two distinct modules, namely the heavy chain of human ferritin (HFt) and a stabilizing/protective PAS polypeptide sequence rich in proline (P), serine (S), and alanine (A) residues. Two genetically fused protein constructs containing PAS polymers… CONTINUE READING

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Selective delivery of doxorubicin by novel stimuli-sensitive nano-ferritins overcomes tumor refractoriness.

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  • 2016
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