Improved Diagnosis of Acute Pulmonary Histoplasmosis by Combining Antigen and Antibody Detection.


BACKGROUND Acute pulmonary histoplasmosis can be severe, especially following heavy inoculum exposure. Rapid diagnosis is critical and often possible by detection of antigen, but this test may be falsely negative in 17% of such cases. Antibody detection by enzyme immunoassay (EIA) may increase sensitivity and permit the measurement of immunoglobulin M (IgM… (More)
DOI: 10.1093/cid/ciw007


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