• Chemistry
  • Published 1983

Improved Delivery Through Biological Membranes XVI Enhancement of the Brain-Specificity of a Dihydropyridine ⇄ Pyridinium Salt Drug Delivery System by Controlled Infusion

@inproceedings{Brewster1983ImprovedDT,
  title={Improved Delivery Through Biological Membranes XVI Enhancement of the Brain-Specificity of a Dihydropyridine ⇄ Pyridinium Salt Drug Delivery System by Controlled Infusion},
  author={Marcus E. Brewster and Nicholas Bodor},
  year={1983}
}
The quaternary salt berberine can be delivered to the brain by injecting the lipoidal dihydroberberine, which is converted in vivo to berberine. The efflux from the brain of the berberine formed in situ is much slower than its rate of elimination from the general circulatory system. This inherent specificity for the brain of this redox delivery system can further be enhanced by slowly infusing the dihydroberberine instead of an i.v. bolus injection. It was found that by controlling infusion of… CONTINUE READING