Improved CNS tolerability following conversion from immediate- to extended-release carbamazepine.

@article{Miller2004ImprovedCT,
  title={Improved CNS tolerability following conversion from immediate- to extended-release carbamazepine.},
  author={April D. Miller and Gregory L. Krauss and Fayez M Hamzeh},
  journal={Acta neurologica Scandinavica},
  year={2004},
  volume={109 6},
  pages={374-7}
}
OBJECTIVES Tolerability of 'narrow therapeutic ratio' (NTR) antiepileptic drugs may improve with uniform drug delivery. We determined whether conversion from immediate-release carbamazepine (IR-CBZ) to extended-release carbamazepine (ER-CBZ) decreased the incidence of CNS side-effects associated with drug concentration oscillations. METHODS We compared CNS side effects and seizure frequency for patients with partial-onset seizures (n = 61) treated with IR-CBZ for > or =1 year with conversion… CONTINUE READING

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