Improved Bioavailability of a Water-Insoluble Drug by Inhalation of Drug-Containing Maltosyl-β-Cyclodextrin Microspheres Using a Four-Fluid Nozzle Spray Drier

  title={Improved Bioavailability of a Water-Insoluble Drug by Inhalation of Drug-Containing Maltosyl-$\beta$-Cyclodextrin Microspheres Using a Four-Fluid Nozzle Spray Drier},
  author={Tetsuya Ozeki and Yoshihito Kano and Norimitsu Takahashi and Tatsuaki Tagami and Hiroaki Okada},
  journal={AAPS PharmSciTech},
We previously developed a unique four-fluid nozzle spray drier that can produce water-soluble microspheres containing water-insoluble drug nanoparticles in one step without any common solvent between the water-insoluble drug and water-soluble carrier. In the present study, we focused on maltosyl-β-cyclodextrin (malt-β-CD) as a new water-soluble carrier and it was investigated whether drug/malt-β-CD microspheres could improve the bioavailability compared with our previously reported drug… 
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