Improved Bioavailability of a Water-Insoluble Drug by Inhalation of Drug-Containing Maltosyl-β-Cyclodextrin Microspheres Using a Four-Fluid Nozzle Spray Drier

@article{Ozeki2012ImprovedBO,
  title={Improved Bioavailability of a Water-Insoluble Drug by Inhalation of Drug-Containing Maltosyl-β-Cyclodextrin Microspheres Using a Four-Fluid Nozzle Spray Drier},
  author={T. Ozeki and Yoshihito Kano and N. Takahashi and T. Tagami and Hiroaki Okada},
  journal={AAPS PharmSciTech},
  year={2012},
  volume={13},
  pages={1130-1137}
}
  • T. Ozeki, Yoshihito Kano, +2 authors Hiroaki Okada
  • Published 2012
  • Chemistry, Medicine
  • AAPS PharmSciTech
    • We previously developed a unique four-fluid nozzle spray drier that can produce water-soluble microspheres containing water-insoluble drug nanoparticles in one step without any common solvent between the water-insoluble drug and water-soluble carrier. In the present study, we focused on maltosyl-β-cyclodextrin (malt-β-CD) as a new water-soluble carrier and it was investigated whether drug/malt-β-CD microspheres could improve the bioavailability compared with our previously reported drug… CONTINUE READING
    View on Springer
    europepmc.org
    7 Citations
    7 Citations
    Citation Type

    Citation Type

    Maltosyl-β-cyclodextrin mediated SupramolecularHost-Guest inclusion complex used for enhancing baicalin antioxidant activity and bioavailability
    Effective spray drying technique to prepare nanocomposite particles by preventing the growth of needle-like simvastatin crystal
    • 1
    Comparison Ability of Polymers Acrycoat S100 And HPMC K4M to Entrapment Efficiency Domperidone in Microspheres
    • PDF
    Improved respirable fraction of budesonide powder for dry powder inhaler formulations produced by advanced supercritical CO2 processing and use of a novel additive.
    • 4
    Pulmonary delivery of tea tree oil‐β‐cyclodextrin inclusion complexes for the treatment of fungal and bacterial pneumonia
    • 6
    Type II diabetes mellitus: a review on recent drug based therapeutics.
    • 2
    Spray drying strategies to stop tuberculosis

    References

    SHOWING 1-10 OF 40 REFERENCES
    One-step preparation of drug-containing microparticles to enhance the dissolution and absorption of poorly water-soluble drugs using a 4-fluid nozzle spray drier.
    • 26
    One-step preparation of rifampicin/poly(lactic-co-glycolic acid) nanoparticle-containing mannitol microspheres using a four-fluid nozzle spray drier for inhalation therapy of tuberculosis.
    • 134
    Microcrystals for dissolution rate enhancement of poorly water-soluble drugs.
    • 199
    Nanosizing: a formulation approach for poorly-water-soluble compounds.
    • 1,111
    Nanosizing for oral and parenteral drug delivery: a perspective on formulating poorly-water soluble compounds using wet media milling technology.
    • 421
    Preparation of drug nanoparticle-containing microparticles using a 4-fluid nozzle spray drier for oral, pulmonary, and injection dosage forms.
    • 44
    Dissolution Rate Enhancement by in Situ Micronization of Poorly Water-Soluble Drugs
    • 237
    Design and Evaluation of an Osmotic Pump Tablet (OPT) for Prednisolone, a Poorly Water Soluble Drug, Using (SBE)7m-β-CD
    • 63
    Formation of Inhalable Rifampicin–Poly(l-lactide) Microparticles by Supercritical Anti-solvent Process
    • 48
    Drug nanocrystals of poorly soluble drugs produced by high pressure homogenisation.
    • C. Keck, R. Mueller
    • Medicine, Chemistry
    • European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
    • 2006
    • 825