Improved Bioavailability of a Water-Insoluble Drug by Inhalation of Drug-Containing Maltosyl-β-Cyclodextrin Microspheres Using a Four-Fluid Nozzle Spray Drier

@article{Ozeki2012ImprovedBO,
  title={Improved Bioavailability of a Water-Insoluble Drug by Inhalation of Drug-Containing Maltosyl-β-Cyclodextrin Microspheres Using a Four-Fluid Nozzle Spray Drier},
  author={T. Ozeki and Yoshihito Kano and N. Takahashi and T. Tagami and Hiroaki Okada},
  journal={AAPS PharmSciTech},
  year={2012},
  volume={13},
  pages={1130-1137}
}
  • T. Ozeki, Yoshihito Kano, +2 authors Hiroaki Okada
  • Published 2012
  • Chemistry, Medicine
  • AAPS PharmSciTech
  • We previously developed a unique four-fluid nozzle spray drier that can produce water-soluble microspheres containing water-insoluble drug nanoparticles in one step without any common solvent between the water-insoluble drug and water-soluble carrier. In the present study, we focused on maltosyl-β-cyclodextrin (malt-β-CD) as a new water-soluble carrier and it was investigated whether drug/malt-β-CD microspheres could improve the bioavailability compared with our previously reported drug… CONTINUE READING
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