Improved Attentional Performance Following Citicoline Administration in Healthy Adult Women

@article{McGlade2012ImprovedAP,
  title={Improved Attentional Performance Following Citicoline Administration in Healthy Adult Women},
  author={Erin C. McGlade and Allison E. Locatelli and Julia M. Hardy and Toshikazu Kamiya and Masahiko Morita and Koji Morishita and Yoichi Sugimura and Deborah A. Yurgelun-Todd},
  journal={Food and Nutrition Sciences},
  year={2012},
  volume={3},
  pages={769-773}
}
Objectives: The present study assessed the potential cognitive-enhancing effects of citicoline, a dietary supplement, in healthy adult women. Specifically, it was hypothesized that citicoline supplementation would be associated with improved attention compared to placebo. Methods: The investigation was a double-blind, randomized, placebo-controlled three-arm study. Sixty healthy adult women ages 40 - 60 completed a clinical screening visit, including a medical exam. After study enrollment each… 

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References

SHOWING 1-10 OF 29 REFERENCES

Therapeutic applications of citicoline for stroke and cognitive dysfunction in the elderly: a review of the literature.

  • R. ConantA. Schauss
  • Biology
    Alternative medicine review : a journal of clinical therapeutic
  • 2004
Citicoline shows promise of clinical efficacy in elderly patients with cognitive deficits, inefficient memory, and early-stage Alzheimer's disease and appears useful for improving both the structural integrity and functionality of the neuronal membrane that may assist in membrane repair.

Chronic citicoline increases phosphodiesters in the brains of healthy older subjects: an in vivo phosphorus magnetic resonance spectroscopy study

The increases in phosphodiesters seen in this study indicate that phospholipid synthesis and turnover were stimulated by 6 weeks of oral citicoline, which supports previous in vitro and animal studies and suggests that the administration of oralciticoline may be of use in reversing age-related changes in the brain.

Citicoline enhances frontal lobe bioenergetics as measured by phosphorus magnetic resonance spectroscopy

Data show that citicoline improves frontal lobe bioenergetics and alters phospholipid membrane turnover and may help to mitigate cognitive declines associated with aging by increasing energy reserves and utilization, as well as increasing the amount of essential phospholIPid membrane components needed to synthesize and maintain cell membranes.

Effect of oral CDP-choline on plasma choline and uridine levels in humans.

Continuous Performance Test Performance in a Normative Epidemiological Sample

Systematic main effects of improved performance with older age were found in this age range for all variables, including reaction time, RT standard error,errors of omission, errors of commission, and signal detection parameters.

Evidence of the neuroprotective role of citicoline in glaucoma patients.

Citicoline Treatment Increases Retinal Dopamine Content in Rabbits

Compared to vehicle-treated controls, citicoline-treated animals displayed a significantly higher retinal dopamine concentration and a tendency toward an increase in adrenaline concentration, while the noradrenaline concentration remained unchanged.

Relations Between Continuous Performance Test Performance Measures and ADHD Behaviors

Overall performance on the two signal detection measures, d' and β, was highly related to all ADHD symptoms across symptom domains, and increased variability in RTs over time was related to most ADHD symptoms.

Stroop performance in healthy younger and older adults and in individuals with dementia of the Alzheimer's type.

The results indicate that older adults show a disproportionate increase in interference compared with younger adults, which is consistent with an inhibitory breakdown in normal aging and an accelerated breakdown in inhibition in DAT individuals.

Association between decline in brain dopamine activity with age and cognitive and motor impairment in healthy individuals.

Age-related decreases in brain dopamine activity are associated with a decline in motor function and may also contribute to impaired performance on tasks that involve frontal brain regions, including measures of abstraction and mental flexibility.