Improperly terminated, unpolyadenylated mRNA of sense transgenes is targeted by RDR6-mediated RNA silencing in Arabidopsis.

@article{Luo2007ImproperlyTU,
  title={Improperly terminated, unpolyadenylated mRNA of sense transgenes is targeted by RDR6-mediated RNA silencing in Arabidopsis.},
  author={Zhenghua Luo and Zhixiang Chen},
  journal={The Plant cell},
  year={2007},
  volume={19 3},
  pages={943-58}
}
RNA silencing can be induced by highly transcribed transgenes through a pathway dependent on RNA-DEPENDENT RNA POLYMERASE6 (RDR6) and may function as a genome protection mechanism against excessively expressed genes. Whether all transcripts or just aberrant transcripts activate this protection mechanism is unclear. Consistent RNA silencing induced by a transgene with three direct repeats of the beta-glucuronidase (GUS) open reading frame (ORF) is associated with high levels of truncated… CONTINUE READING
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Intrinsic direct repeats generate consistent post-transcriptional gene silencing in tobacco.

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