Improbability of effective vaccination against human immunodeficiency virus because of its intracellular transmission and rectal portal of entry.

  • A. B. Sabin
  • Published 1992 in
    Proceedings of the National Academy of Sciences…


The worldwide effort to produce a vaccine against AIDS continues to disregard the fact that even human immunodeficiency virus (HIV)-specific neutralizing antibodies and cell-mediated immunity are ineffective against virus within cells without viral antigens on the cell membrane--and that much of HIV infection is transmitted in this manner. According to a… (More)


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