Imprinting mechanisms in mammals.

  title={Imprinting mechanisms in mammals.},
  author={Wolf Reik and Joachim Walter},
  journal={Current opinion in genetics & development},
  volume={8 2},
Imprinting is a genetic mechanism that determines expression or repression of genes according to their parental origin. Some imprinted genes occur in clusters in the genome. Recent work using transgenic mice shows that multiple cis-acting sequences are needed for correct imprinting. Mutation analysis in a normal chromosomal context reveals the importance of imprinting centres for regional establishment or maintenance of imprinting in a cluster. Elements that contribute to the function of… CONTINUE READING