Imprinting in the schizophrenia candidate gene GABRB2 encoding GABAA receptor β2 subunit

@article{Pun2011ImprintingIT,
  title={Imprinting in the schizophrenia candidate gene GABRB2 encoding GABAA receptor β2 subunit},
  author={Frank W. Pun and C Zhao and W-S Lo and S Ng and S. Tsang and Vishwajit L. Nimgaonkar and Woo Sik Chung and G{\'a}bor S{\'a}ndor Ungvari and Hong Xue},
  journal={Molecular Psychiatry},
  year={2011},
  volume={16},
  pages={557-568}
}
Schizophrenia is a complex genetic disorder, the inheritance pattern of which is likely complicated by epigenetic factors yet to be elucidated. In this study, transmission disequilibrium tests with family trios yielded significant differences between paternal and maternal transmissions of the disease-associated single-nucleotide polymorphism (SNP) rs6556547 and its haplotypes. The minor allele (T) of rs6556547 was paternally undertransmitted to male schizophrenic offsprings, and this parent-of… CONTINUE READING

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