Imprinting in clusters: lessons from Beckwith-Wiedemann syndrome.

Abstract

Imprinted genes in mammals can be clustered in the genome. This raises important questions about mechanistic and functional relationships between imprinted genes in a cluster. The insulin-like growth factor II (IGF2) gene is paternally expressed and is surrounded by maternally expressed genes. Loss of imprinting of IGF2 is the most common molecular defect… (More)

Topics

  • Presentations referencing similar topics