Imprinting and the epigenetic asymmetry between parental genomes.

  title={Imprinting and the epigenetic asymmetry between parental genomes.},
  author={Anne C Ferguson-Smith and M. Azim Surani},
  volume={293 5532},
Genomic imprinting confers a developmental asymmetry on the parental genomes, through epigenetic modifications in the germ line and embryo. These heritable modifications regulate the monoallelic activity of parental alleles resulting in their functional differences during development. Specific cis-acting regulatory elements associated with imprinted genes carry modifications involving chromatin structural changes and DNA methylation. Some of these modifications are initiated in the germ line… CONTINUE READING