Imprinting and the Initiation of Gene Silencing in the Germ Line

  title={Imprinting and the Initiation of Gene Silencing in the Germ Line},
  author={M. Azim Surani},
of loss of function of paternal and maternal allele-specific genes, respectively (Dittrich et al., 1996). Many imprinted genes here, including SNRPN, are unmethylated on the paternal chromosome but methylated on the maternal chromosome. Mutations within the SNRPN exon 1 region cause PWS, and those that occur further upstream and affect certain RNA (BD) transcripts cause AS. The imprinting center (IC) responsible for initiating the epigenetic switch in the germ line is therefore pro-Inheritance… CONTINUE READING
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