Imprinted noncoding RNAs

@article{Peters2008ImprintedNR,
  title={Imprinted noncoding RNAs},
  author={Jo Peters and Joan E. Robson},
  journal={Mammalian Genome},
  year={2008},
  volume={19},
  pages={493-502}
}
Imprinted genes are silenced in a parental-specific manner and tend to occur in clusters. All well-characterised imprinted clusters contain noncoding RNAs that are silenced according to parental origin. These can be broadly classified into long noncoding RNAs and short regulatory RNAs. Functional testing has shown that long noncoding RNAs can be crucial imprinting elements and act in cis throughout the cluster to silence protein-coding genes. Whether silencing occurs via transcription of the… CONTINUE READING

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