Imprinted X inactivation in eutherians: a model of gametic execution and zygotic relaxation.

@article{Huynh2001ImprintedXI,
  title={Imprinted X inactivation in eutherians: a model of gametic execution and zygotic relaxation.},
  author={Khanh Huynh and Jeannie T Lee},
  journal={Current opinion in cell biology},
  year={2001},
  volume={13 6},
  pages={
          690-7
        }
}
In mammals, X-chromosome inactivation (XCI) ensures equal expression of X-linked genes in XX and XY individuals by transcriptionally silencing one X-chromosome in female cells. In this review, we discuss an imprinted form of X-inactivation in which the paternal X (Xp) is preferentially silenced. Believed to be the ancestral mechanism of dosage compensation in mammals, imprinted X-inactivation can still be observed in modern-day marsupials and in the extraembryonic tissues of some eutherians… CONTINUE READING

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