Imprinted Gene Dosage Is Critical for the Transition to Independent Life

@inproceedings{Charalambous2012ImprintedGD,
  title={Imprinted Gene Dosage Is Critical for the Transition to Independent Life},
  author={Marika Charalambous and Sacramento Rodriguez Ferr{\'o}n and Simao T. da Rocha and Andrew John Murray and T. Rowland and Mitsuteru Ito and Karin Schuster-Gossler and Arturo Hern{\'a}ndez and Anne C Ferguson-Smith},
  booktitle={Cell metabolism},
  year={2012}
}
Neonatal survival in mammals is crucially dependent upon maintenance of body temperature. Neonatal body temperature is largely maintained by thermogenesis in brown adipose tissue (BAT). BAT develops perinatally in mice requiring integration of adipogenic and thermoregulatory gene pathways. We describe a regulatory mutation in the imprinted gene cluster on mouse chromosome 12 resulting in early postnatal lethality. Maternal inheritance of this mutation impairs the ability of young mice to… CONTINUE READING

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