Impossibility of multiple steady states in a family of active membrane transport models

  • Hsing-Ya Li
  • Published 1999 in European Biophysics Journal

Abstract

To study the dynamical behavior of active membrane transport models, Vieira and Bisch proposed a complex chemical network (model 3) with two cycles. One cycle involves monomers as pump units while the other cycle uses dimers. In their work, the stoichiometric network analysis was used to study the stability of steady states and the bifurcation analysis was done through numerical methods. They concluded that the possibility of multiple steady states in the model 3 could not be discarded. Here, a zero eigenvalue analysis is applied to prove the impossibility of multiple positive steady states in the model 3. (A positive steady state is one for which all species have positive concentrations.) Moreover, the result is generalized to its family networks.

DOI: 10.1007/s002490050207

Cite this paper

@article{Li1999ImpossibilityOM, title={Impossibility of multiple steady states in a family of active membrane transport models}, author={Hsing-Ya Li}, journal={European Biophysics Journal}, year={1999}, volume={28}, pages={259-262} }