Importins and exportins in cellular differentiation

  title={Importins and exportins in cellular differentiation},
  author={Norihisa Okada and Yoko Ishigami and Takuji Suzuki and A. Kaneko and Kensuke Yasui and Ryuuta Fukutomi and Mamoru Isemura},
  booktitle={Journal of cellular and molecular medicine},
The importin/exportin transport system provides the machinery involved in nucleocytoplasmic transport. Alterations of the levels of importins and exportins may play crucial roles in development, differentiation and transformation. Employing human leukaemia HL-60 cells, we and others have revealed the differentiation-associated changes in the protein and gene expression of these factors. The recent finding that a switch to the importin-alpha subtype triggers neural differentiation of embryonic… CONTINUE READING