Importin alpha: a multipurpose nuclear-transport receptor.

  title={Importin alpha: a multipurpose nuclear-transport receptor.},
  author={David S. Goldfarb and Anita H. Corbett and D. Adam Mason and Michelle T. Harreman and Stephen A. Adam},
  journal={Trends in cell biology},
  volume={14 9},
The importin alpha/beta heterodimer targets hundreds of proteins to the nuclear-pore complex (NPC) and facilitates their translocation across the nuclear envelope. Importin alpha binds to classical nuclear localization signal (cNLS)-containing proteins and links them to importin beta, the karyopherin that ferries the ternary complex through the NPC. A second karyopherin, the exportin CAS, recycles importin alpha back to the cytoplasm. In this article, we discuss control mechanisms that importin… CONTINUE READING
Highly Influential
This paper has highly influenced 23 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

From This Paper

Topics from this paper.
189 Citations
0 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 189 extracted citations

Similar Papers

Loading similar papers…