Importin alpha/beta and Ran-GTP regulate XCTK2 microtubule binding through a bipartite nuclear localization signal.

@article{EmsMcClung2004ImportinAA,
  title={Importin alpha/beta and Ran-GTP regulate XCTK2 microtubule binding through a bipartite nuclear localization signal.},
  author={Stephanie C Ems-McClung and Yixian Zheng and Claire E Walczak},
  journal={Molecular biology of the cell},
  year={2004},
  volume={15 1},
  pages={
          46-57
        }
}
The small GTPase Ran is essential for spindle assembly. Ran is proposed to act through its nuclear import receptors importin alpha and/or importin beta to control the sequestration of proteins necessary for spindle assembly. To date, the molecular mechanisms by which the Ran pathway functions remain unclear. Using purified proteins, we have reconstituted Ran-regulated microtubule binding of the C-terminal kinesin XCTK2, a kinesin important for spindle assembly. We show that the tail of XCTK2… CONTINUE READING

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