Importin 8 mediates m7G cap-sensitive nuclear import of the eukaryotic translation initiation factor eIF4E.

@article{Volpon2016Importin8M,
  title={Importin 8 mediates m7G cap-sensitive nuclear import of the eukaryotic translation initiation factor eIF4E.},
  author={Laurent Volpon and Biljana Culjkovic-Kraljacic and Michael J. Osborne and Anup Ramteke and Qingxiang Sun and Ashley Niesman and Yuh Min Chook and Katherine L. B. Borden},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2016},
  volume={113 19},
  pages={
          5263-8
        }
}
Regulation of nuclear-cytoplasmic trafficking of oncoproteins is critical for growth homeostasis. Dysregulated trafficking contributes to malignancy, whereas understanding the process can reveal unique therapeutic opportunities. Here, we focus on eukaryotic translation initiation factor 4E (eIF4E), a prooncogenic protein highly elevated in many cancers, including acute myeloid leukemia (AML). Typically, eIF4E is localized to both the nucleus and cytoplasm, where it acts in export and… CONTINUE READING
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