Importin 7 and importin alpha/importin beta are nuclear import receptors for the glucocorticoid receptor.

@article{Freedman2004Importin7A,
  title={Importin 7 and importin alpha/importin beta are nuclear import receptors for the glucocorticoid receptor.},
  author={Neal D. Freedman and Keith R. Yamamoto},
  journal={Molecular biology of the cell},
  year={2004},
  volume={15 5},
  pages={
          2276-86
        }
}
The vertebrate glucocorticoid receptor (GR) is cytoplasmic without hormone and localizes to the nucleus after hormone binding. GR has two nuclear localization signals (NLS): NL1 is similar in sequence to the SV40 NLS; NL2 is poorly defined, residing in the ligand-binding domain. We found that GR displayed similar hormone-regulated compartmentalization in Saccharomyces cerevisiae and required the Sxm1 nuclear import receptor for NL2-mediated import. Two metazoan homologues of Sxm1, importin 7… CONTINUE READING

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