Importin-11 Regulates Synaptic Phosphorylated Mothers Against Decapentaplegic , and Thereby Influences Synaptic Development and Function at the Drosophila Neuromuscular Junction

@inproceedings{HigashiKovtun2010Importin11RS,
  title={Importin-11 Regulates Synaptic Phosphorylated Mothers Against Decapentaplegic , and Thereby Influences Synaptic Development and Function at the Drosophila Neuromuscular Junction},
  author={Misao E. Higashi-Kovtun and Timothy J Mosca and Dion K Dickman and Ian A. Meinertzhagen and Thomas L Schwarz},
  year={2010}
}
Importin proteins act both at the nuclear pore to promote substrate entry and in the cytosol during signal trafficking. Here, we describe mutations in the Drosophila gene importin11, which has not previously been analyzed genetically. Mutants of importin11 died as late pupae from neuronal defects, and neuronal importin11 was present not only at nuclear pores but also in the cytosol and at synapses. Neurons lacking importin11 were viable and properly differentiated but exhibited discrete defects… CONTINUE READING
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The regulation of phosphorylation of a specific protein in synaptosomal fractions from Drosophila heads: the effects of light and two visual mutants

  • LE Kelly
  • Cell Mol Neurobiol
  • 1983
Highly Influential
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