Importin-β modulates the permeability of the nuclear pore complex in a Ran-dependent manner

@inproceedings{Lowe2015ImportinMT,
  title={Importin-β modulates the permeability of the nuclear pore complex in a Ran-dependent manner},
  author={Alan R Lowe and Jeffrey H Tang and Jaime M Yassif and Michael Graf and William Y C Huang and Jay T. Groves and Karsten Weis and Jan T. Liphardt},
  booktitle={eLife},
  year={2015}
}
Soluble karyopherins of the importin-β (impβ) family use RanGTP to transport cargos directionally through the nuclear pore complex (NPC). Whether impβ or RanGTP regulate the permeability of the NPC itself has been unknown. In this study, we identify a stable pool of impβ at the NPC. A subpopulation of this pool is rapidly turned-over by RanGTP, likely at Nup153. Impβ, but not transportin-1 (TRN1), alters the pore's permeability in a Ran-dependent manner, suggesting that impβ is a functional… CONTINUE READING