Importin β contains a COOH-terminal nucleoporin binding region important for nuclear transport

@article{Bednenko2003ImportinC,
  title={Importin β contains a COOH-terminal nucleoporin binding region important for nuclear transport},
  author={Janna Bednenko and Gino Cingolani and Larry Gerace},
  journal={The Journal of Cell Biology},
  year={2003},
  volume={162},
  pages={391 - 401}
}
  • Janna Bednenko, Gino Cingolani, Larry Gerace
  • Published in The Journal of cell biology 2003
  • Biology, Medicine
  • The Journal of Cell Biology
  • Proteins containing a classical NLS are transported into the nucleus by the import receptor importin beta, which binds to cargoes via the adaptor importin alpha. The import complex is translocated through the nuclear pore complex by interactions of importin beta with a series of nucleoporins. Previous studies have defined a nucleoporin binding region in the NH2-terminal half of importin beta. Here we report the identification of a second nucleoporin binding region in its COOH-terminal half… CONTINUE READING

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