Importin β–Mediated Nuclear Import of Fibroblast Growth Factor Receptor

@article{Reilly2001ImportinN,
  title={Importin β–Mediated Nuclear Import of Fibroblast Growth Factor Receptor},
  author={John F. Reilly and Pamela A. Maher},
  journal={The Journal of Cell Biology},
  year={2001},
  volume={152},
  pages={1307 - 1312}
}
Although growth factor receptors are generally thought to carry out their role in signal transduction at the cell surface, many of these transmembrane proteins translocate to the nucleus after ligand stimulation. Here, we show that the nuclear translocation of fibroblast growth factor receptor (FGFR)1 occurs via a mechanism distinct from classical nuclear import but dependent on importin beta, a component of multiple nuclear import pathways. Furthermore, we show that nuclear FGFR1 induces c-Jun… CONTINUE READING

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