Importin α/β mediates nuclear import of individual SUMO E1 subunits and of the holo-enzyme

Abstract

SUMOylation, reversible attachment of small ubiquitin-related modifier (SUMO), serves to regulate hundreds of proteins. Consistent with predominantly nuclear targets, enzymes required for attachment and removal of SUMO are highly enriched in this compartment. This is true also for the first enzyme of the SUMOylation cascade, the SUMO E1 enzyme heterodimer… (More)
DOI: 10.1091/mbc.E10-05-0461

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