Important roles of the AKR1C2 and SRD5A1 enzymes in progesterone metabolism in endometrial cancer model cell lines.

@article{Sinreih2015ImportantRO,
  title={Important roles of the AKR1C2 and SRD5A1 enzymes in progesterone metabolism in endometrial cancer model cell lines.},
  author={Ma{\vs}a Sinreih and Maja Anko and Sven Zukunft and Jerzy Adamski and Tea Lanisnik Rizner},
  journal={Chemico-biological interactions},
  year={2015},
  volume={234},
  pages={297-308}
}
Endometrial cancer is the most frequently diagnosed gynecological malignancy. It is associated with prolonged exposure to estrogens that is unopposed by progesterone, whereby enhanced metabolism of progesterone may decrease its protective effects, as it can deprive progesterone receptors of their active ligand. Furthermore, the 5α-pregnane metabolites… CONTINUE READING