Important role of hydrogen bonds in the structurally polarized transition state for folding of the src SH3 domain

@article{Grantcharova1998ImportantRO,
  title={Important role of hydrogen bonds in the structurally polarized transition state for folding of the src SH3 domain},
  author={Viara P. Grantcharova and David S. Riddle and Jed V. Santiago and David Baker},
  journal={Nature Structural &Molecular Biology},
  year={1998},
  volume={5},
  pages={714-720}
}
Experimental and theoretical studies on the folding of small proteins such as the chymotrypsin inhibitor 2 (CI-2) and the P22 Arc repressor suggest that the folding transition state is an expanded version of the native state with most interactions partially formed. Here we report that this picture does not hold generally: a hydrogen bond network involving two β-turns and an adjacent hydrophobic cluster appear to be formed in the folding transition state of the src SH3 domain, while the… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.
86 Citations
39 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 86 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 39 references

Similar Papers

Loading similar papers…