Important role of endogenous norepinephrine and epinephrine in the development of in vivo pressure-overload cardiac hypertrophy.

@article{Rapacciuolo2001ImportantRO,
  title={Important role of endogenous norepinephrine and epinephrine in the development of in vivo pressure-overload cardiac hypertrophy.},
  author={Antonio Rapacciuolo and Giovanni Esposito and Kathleen M Caron and Lan Mao and Steven Abbe Thomas and Howard A Rockman},
  journal={Journal of the American College of Cardiology},
  year={2001},
  volume={38 3},
  pages={
          876-82
        }
}
OBJECTIVES We sought to define the role of norepinephrine and epinephrine in the development of cardiac hypertrophy and to determine whether the absence of circulating catecholamines alters the activation of downstream myocardial signaling pathways. BACKGROUND Cardiac hypertrophy is associated with elevated plasma catecholamine levels and an increase in cardiac morbidity and mortality. Although considerable evidence suggests that G-protein-coupled receptors are involved in the hypertrophic… CONTINUE READING

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