Important role of apoptosis signal-regulating kinase 1 in ischemic acute kidney injury.

@article{Terada2007ImportantRO,
  title={Important role of apoptosis signal-regulating kinase 1 in ischemic acute kidney injury.},
  author={Yoshio Terada and Seiji Inoshita and Hitoshi Kuwana and Takahiko Kobayashi and Tomokazu Okado and Hidenori Ichijo and Sei Sasaki},
  journal={Biochemical and biophysical research communications},
  year={2007},
  volume={364 4},
  pages={1043-9}
}
We investigated the role of apoptosis signal-regulating kinase 1 (ASK1) in ischemia/reperfusion (I/R)-induced acute kidney injury (AKI). Blood urea nitrogen (BUN) and serum creatinine were significantly higher in ASK1+/+ mice than in ASK1-/- mice after I/R injury. Renal histology of ASK1+/+ mice showed significantly greater tubular necrosis and degradation. In ASK1-/- mice, phosphorylation of ASK1, JNK, and p38K, and the number of TUNEL-positive cells and infiltrated leukocytes decreased after… CONTINUE READING

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