Important pharmacophores for binding to galanin receptor 2.

  title={Important pharmacophores for binding to galanin receptor 2.},
  author={Linda Lundstr{\"o}m and Xiaoying Lu and U Lo Langel and Tamas Bartfai},
  volume={39 3},
Galanin(2-11) has been introduced as a receptor subtype selective ligand for the GalR2 subtype of the galanin receptors, and has gained use in pharmacological studies of galaninergic signaling in the past two years. By introducing l-Ala substitutions in the galanin(2-11) sequence, we have examined the amino acid residues which are of importance for binding to the GalR2 receptor. Our study shows that Trp2, Asn5, Gly8 and Tyr9 are of great importance for high affinity binding. When placed in an… CONTINUE READING

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