Important issues in the design and reporting of clinical trials in severe sepsis and acute lung injury.

@article{Dellinger2008ImportantII,
  title={Important issues in the design and reporting of clinical trials in severe sepsis and acute lung injury.},
  author={Richard Phillip Dellinger and J K Vincent and John C. Marshall and Konrad A Reinhart},
  journal={Journal of critical care},
  year={2008},
  volume={23 4},
  pages={493-9}
}
Severe sepsis and acute lung injury are challenging diagnoses as they relate to designing and reporting of clinical trials. The limited success in bringing forward new therapies in these areas is likely proof of that premise. The ability to use preclinical and phase I and II trial data to predict which patients and which dosing regimens are more likely to benefit is perhaps the greatest challenge. Animal models continue to be refined in attempts to more accurately reproduce human sepsis and… CONTINUE READING