Important drugs for cough in advanced cancer

@article{Homsi2001ImportantDF,
  title={Important drugs for cough in advanced cancer},
  author={Jade Homsi and Declan Walsh and Kristine A. Nelson},
  journal={Supportive Care in Cancer},
  year={2001},
  volume={9},
  pages={565-574}
}
Abstract. Cough is a defense mechanism that prevents the entry of noxious materials into the respiratory system and clears foreign materials and excess secretions from the lungs and respiratory tract. In advanced cancer, it is a common symptom that interferes with the patient's daily activity and quality of life. Empiric treatment with antitussive agents is often needed. Two classes of antitussive drugs are available: (1) centrally acting: (a) opioids and (b) nonopioids; (2) peripherally acting… 

Chronic cough

  • B. Wee
  • Medicine
    Current opinion in supportive and palliative care
  • 2008
The availability of simple assessment tools places the imperative on clinicians to be more systematic in assessment of cough and its interventions, and the mainstay of oral therapy for symptom control remains dextromethorphan, codeine and morphine.

Management of cough in advanced cancer.

Managing cough is directed at correcting the reversible causes, and hydrocodone is preferred as first-line empiric treatment, but when the cough is resistant to this, the second-line therapy would be the addition or substitution of benzonatate.

Shortness of breath and cough in patients in palliative care.

In most patients, shortness of breath and cough can be relieved by a series of therapeutic measures, and opioids, including morphine and dextromethorphan, are effective antitussants with low toxicity.

Chronic Cough Due to Lung Tumors

Goals/objectives: To review the scientific evidence on cough associated with tumors in the lungs. Methods: MEDLINE literature review (through March 2004) for all studies published in the English

Chronic cough due to lung tumors: ACCP evidence-based clinical practice guidelines.

The scientific evidence on cough associated with tumors in the lungs is reviewed, showing that lung cancer is the cause of chronic cough in <or=2% of all patients who present with a chronic cough.

Levodropropizine in the Management of Cough Associated with Cancer or Nonmalignant Chronic Disease–A Systematic Review

The authors conclude that the evidence for the antitussive efficacy of levodropropizine in these patients is scarce, and is further limited by the methodological weaknesses of the primary studies.

Pharmacological modulation of cough reflex

Interventions for cough in cancer.

Overall, there was an absence of credible evidence and the majority of studies were of low methodological quality and at high risk of bias, suggesting that possibly the lowest effective dose should be used to minimise side effects.
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