Important drugs for cough in advanced cancer

@article{Homsi2001ImportantDF,
  title={Important drugs for cough in advanced cancer},
  author={J. Homsi and D. Walsh and K. Nelson},
  journal={Supportive Care in Cancer},
  year={2001},
  volume={9},
  pages={565-574}
}
Abstract. Cough is a defense mechanism that prevents the entry of noxious materials into the respiratory system and clears foreign materials and excess secretions from the lungs and respiratory tract. In advanced cancer, it is a common symptom that interferes with the patient's daily activity and quality of life. Empiric treatment with antitussive agents is often needed. Two classes of antitussive drugs are available: (1) centrally acting: (a) opioids and (b) nonopioids; (2) peripherally acting… Expand
Chronic cough
  • B. Wee
  • Medicine
  • Current opinion in supportive and palliative care
  • 2008
TLDR
The availability of simple assessment tools places the imperative on clinicians to be more systematic in assessment of cough and its interventions, and the mainstay of oral therapy for symptom control remains dextromethorphan, codeine and morphine. Expand
Management of cough in advanced cancer.
TLDR
Managing cough is directed at correcting the reversible causes, and hydrocodone is preferred as first-line empiric treatment, but when the cough is resistant to this, the second-line therapy would be the addition or substitution of benzonatate. Expand
Shortness of breath and cough in patients in palliative care.
TLDR
In most patients, shortness of breath and cough can be relieved by a series of therapeutic measures, and opioids, including morphine and dextromethorphan, are effective antitussants with low toxicity. Expand
Chronic cough due to lung tumors: ACCP evidence-based clinical practice guidelines.
TLDR
The scientific evidence on cough associated with tumors in the lungs is reviewed, showing that lung cancer is the cause of chronic cough in <or=2% of all patients who present with a chronic cough. Expand
Levodropropizine in the Management of Cough Associated with Cancer or Nonmalignant Chronic Disease–A Systematic Review
TLDR
The authors conclude that the evidence for the antitussive efficacy of levodropropizine in these patients is scarce, and is further limited by the methodological weaknesses of the primary studies. Expand
Pharmacological modulation of cough reflex
TLDR
In this chapter the authors divided the drugs used in the pharmacological treatment of cough into several groups, which include the drugs acting at the level of receptors, the drugs affecting the propagation of cough impulses in afferent nerves, the drug modulating the central coordination of cough reflex, the Drugs acting atThe level of efferent nerve, and the drugs affected the effectors. Expand
The cough from hell: diazepam for intractable cough in a patient with renal cell carcinoma.
TLDR
The case of a patient with renal cell carcinoma hospitalized for intractable cough that failed to respond adequately to usual treatments, but improved with diazepam is presented. Expand
Symptomatic Treatment of Cough Among Adult Patients With Lung Cancer: CHEST Guideline and Expert Panel Report
TLDR
Compared with the 2006 CHEST Cough Guideline, the current recommendations and suggestions are more specific and follow a step-up approach to the management of cough among patients with lung cancer, acknowledging the low-quality evidence in the field and the urgent need to develop more effective, evidence-based interventions through high-quality research. Expand
Symptomatic Treatment of Cough Among Adult Patients With Lung Cancer: CHEST Guideline and Expert Panel Report
TLDR
Compared with the 2006 CHEST Cough Guideline, the current recommendations and suggestions are more specific and follow a step‐up approach to the management of cough among patients with lung cancer, acknowledging the low‐quality evidence in the field and the urgent need to develop more effective, evidence‐based interventions through high‐quality research. Expand
Interventions for cough in cancer.
TLDR
Overall, there was an absence of credible evidence and the majority of studies were of low methodological quality and at high risk of bias, suggesting that possibly the lowest effective dose should be used to minimise side effects. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 98 REFERENCES
SYMPTOMATIC TREATMENT OF ASTHMATIC BRONCHITIS
  • S. Simon
  • Medicine
  • Journal of the American Geriatrics Society
  • 1960
TLDR
This paper concerns itself with the results of a double-blind study to assess the value of benzonatate when used in this liquid form to add the antitussive agent to a cough mixture rather than give two such medications separately. Expand
Benzonatate for opioid-resistant cough in advanced cancer
TLDR
It is reported three patients with an opioid-resistant cough who achieved symptomatic relief with the peripherally acting nonopioid drug benzonatate. Expand
Efficacy and safety of levodropropizine and dihydrocodeine on nonproductive cough in primary and metastatic lung cancer.
TLDR
The antitussive effectiveness of levodropropizine is confirmed and a more favourable benefit/risk profile when compared to dihydrocodeine is suggested. Expand
Management of dyspnea and cough in patients with cancer.
TLDR
A need exists for more research to determine the most effective management of dyspnea, a common and very distressing symptom of cancer patients. Expand
A phase II study of hydrocodone for cough in advanced cancer
TLDR
Cough severity, frequency, associated symptoms and complications, and activities of daily living improved significantly and a starting dose of 10 mg per day in divided doses seems effective. Expand
Hydrocodone for cough in advanced cancer
TLDR
The highest median duration of treatment was for esophageal cancer and the highest median maximum daily dose and total dose were for treating kidney cancer, while lung cancer as a primary cancer site was strongly related to the use of hydrocodone. Expand
Dextromethorphan and Codeine: Objective Assessment of Antitussive Activity in Patients with Chronic Cough
TLDR
Dextromethorphan, the most widely used cough suppressant in the U.S.A., was compared with codeine in a double-blind, crossover trial and was considered the better antitussive by the majority of patients. Expand
Fixed-drug eruption due to dextromethorphan.
TLDR
A healthy 45-year-old woman who had been using antitussive drugs containing dextromethorphan for two or three periods of 2 to 3 weeks a year developed an erythematous patch, 3 cm in diameter, on her right upper arm in March 1989. Expand
Management of Intractable Cough
TLDR
The patient diedpeacefully and free of cough, 16 days after the last dose of narcotic treatment, with very successful coughcontrol. Expand
Symptom control in advanced cancer: important drugs and routes of administration.
TLDR
This article will discuss some drugs presently available to achieve good symptom control, and the list presented here is not exhaustive, but does reflect core drugs currently available in the United States. Expand
...
1
2
3
4
5
...