Important drug interactions in hematopoietic stem cell transplantation: what every physician should know.

@article{Glotzbecker2012ImportantDI,
  title={Important drug interactions in hematopoietic stem cell transplantation: what every physician should know.},
  author={Brett E Glotzbecker and Christine N. Duncan and Edwin P Alyea and Bonnie J Campbell and Robert J. Soiffer},
  journal={Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation},
  year={2012},
  volume={18 7},
  pages={989-1006}
}
Morbidity is increased in patients undergoing hematopoietic stem cell transplantation when drug-drug interactions lead to unexpected outcomes. These interactions occur as a result of exposure to complicated medical regimens with drugs with narrow therapeutic windows and high toxicity profiles. In this report, we review the available evidence and possible mechanisms of the most clinically relevant drug interactions, including those involving inhibitors and inducers of the P450 isoenzyme system… CONTINUE READING
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