Important aspects of Toll-like receptors, ligands and their signaling pathways

@article{Chang2010ImportantAO,
  title={Important aspects of Toll-like receptors, ligands and their signaling pathways},
  author={ZeNan L Chang},
  journal={Inflammation Research},
  year={2010},
  volume={59},
  pages={791-808}
}
Due to the rapid increase of new information on the multiple roles of Toll-like receptors (TLRs), this paper reviews several main properties of TLRs and their ligands and signaling pathways. The investigation of pathogen infections in knockout mice suggests that specific TLRs play a key role in the activation of immune responses. Although the investigation of TLR biology is just beginning, a number of important findings are emerging. This review focuses on the following seven aspects of this… CONTINUE READING
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