Important Controversies Associated with Isotretinoin Therapy for Acne

@article{Wolverton2013ImportantCA,
  title={Important Controversies Associated with Isotretinoin Therapy for Acne},
  author={S. Wolverton and J. Harper},
  journal={American Journal of Clinical Dermatology},
  year={2013},
  volume={14},
  pages={71-76}
}
Isotretinoin is a remarkably effective drug for severe, recalcitrant acne vulgaris. Soon after the drug’s release in the early 1980s, a number of important adverse effects were reported subsequently leading to a variety of medical and medicolegal controversies. Three of these controversies will be highlighted concerning the putative role of isotretinoin in (1) depression and suicide, (2) inflammatory bowel disease, and (3) iPledge and pregnancy prevention programs. It appears that a very small… Expand
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TLDR
Isotretinoin does not appear to be associated with the development of depression, and denying patients with significant acne an effective medication for fear of developing depression may not be indicated at this point in time. Expand
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TLDR
The results provide no relationship between isotretinoin use and depression in acne patients and Improvement in anxiety was detected later than the improvement in depressive symptoms and a statistically significant difference was detected between the first and the second follow-up. Expand
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TLDR
Results indicate that oral isotretinoin therapy alleviates depressive symptoms and improvements in depression are directly related to acne‐related life quality improvements rather than to improvement in acne grade. Expand
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TLDR
There is no known pharmacological mechanism that would account for psychiatric symptomatology as a result of isotretinoin treatment; however, retinoid receptors are widely distributed in the brain and more research is needed to ascertain whether they have a role in depression. Expand
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TLDR
This pilot study was unable to detect an association between the use of isotretinoin and an increased risk for anxiety, depression, or suicidal thoughts. Expand
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TLDR
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