Importances of Polar Groups for initiating Blood Coagulation and aggregating Platelets

@article{Nossel1969ImportancesOP,
  title={Importances of Polar Groups for initiating Blood Coagulation and aggregating Platelets},
  author={Hymie L. Nossel and George D Wilner and Elizabeth C Leroy},
  journal={Nature},
  year={1969},
  volume={221},
  pages={75-76}
}
HAEMOSTASIS and thrombosis are thought to involve a reaction between the blood and the diseased or damaged walls of blood vessels, but little is known about the chemical nature of the process. It is, however, known that collagen, which is present in the walls of blood vessels, will aggregate platelets in vitro1,2 and will also initiate the blood clotting mechanism3,4. These properties of native collagen with an intact triple helical structure are, however, lacking in the denatured random coil… CONTINUE READING

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