Importance of the use of the appropriate pharmacokinetic model to analyzein vivo enzyme constants

@article{Sedman1974ImportanceOT,
  title={Importance of the use of the appropriate pharmacokinetic model to analyzein vivo enzyme constants},
  author={Allen J. Sedman and John E Wagner},
  journal={Journal of Pharmacokinetics and Biopharmaceutics},
  year={1974},
  volume={2},
  pages={161-173}
}
Throughout the literature, enzyme constants have been derived by utilizing in vivodata and indirectly assuming that these data were described by the one-compartment open model. However, many drugs are probably best described by a two-compartment open model with Michaelis-Menten elimination kinetics. Simulated data, which obey the two-compartment open model with Michaelis-Menten elimination, and which illustrate some of the interesting properties of such models, are presented. Treatment of two… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

References

Publications referenced by this paper.
Showing 1-8 of 8 references

Thiopental pharmacokinetics.

Journal of pharmaceutical sciences • 1968

and G

H. N. Christense
A. Palmer. Enzyme Kinetics, Saunders, Philadelphia, • 1967

Liver alcohol dehydrogenase : Kinetic and physicochemical properties

J. P. Von Wartburg, J. L. Bethune, B. L. Vallee
Biochemistry • 1964

Similar Papers

Loading similar papers…