• Biology, Medicine
  • Published in
    Frontiers in bioscience : a…
    2001
  • DOI:10.2741/Dennis

Importance of the regulation of nuclear receptor degradation.

@article{Dennis2001ImportanceOT,
  title={Importance of the regulation of nuclear receptor degradation.},
  author={Andrew P. Dennis and R U Haq and Zafar Nawaz},
  journal={Frontiers in bioscience : a journal and virtual library},
  year={2001},
  volume={6},
  pages={
          D954-9
        }
}
Nuclear hormone receptors (NHRs) represent a superfamily of structurally related ligand-activated transcription factors, which regulate diverse biological activities like growth, development, and homeostasis. Recently, it has been demonstrated that certain members of the NHR superfamily are degraded through the ubiquitin-proteasome pathway in a ligand-dependent manner. Though the signal for the down-regulation via the ubiquitin-proteasome pathway is not yet known, phosphorylation at specific… CONTINUE READING

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