Importance of the polarity of the glycosaminoglycan chain on the interaction with FGF-1.

Abstract

Heparin-like saccharides play an essential role in binding to the fibroblast growth factor (FGF)-1 and to their membrane receptors fibroblast growth factor receptor forming a ternary complex that is responsible of the internalization of the signal, via the dimerization of the intracellular regions of the receptor. In this study, we report the binding… (More)
DOI: 10.1093/glycob/cwu071

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