Importance of the paracellular pathway for the transport of a new bisphosphonate using the human CACO-2 monolayers model.

@article{Boulenc1993ImportanceOT,
  title={Importance of the paracellular pathway for the transport of a new bisphosphonate using the human CACO-2 monolayers model.},
  author={Xavier Boulenc and Elisa Mart{\'i} and H M Joyeux and Claude Roques and Yves Berger and G{\'e}rard Fabre},
  journal={Biochemical pharmacology},
  year={1993},
  volume={46 9},
  pages={1591-600}
}
The transport of a new bisphosphonate, Tiludronate, was investigated on the human adenocarcinoma cell line, CACO-2. Experiments were performed 7-16 days after cells achieved confluence, conditions under which they form well-differentiated monolayers joined by tight junctions. Tiludronate transport rate across CACO-2 monolayers was independent of the temperature (4 degrees versus 37 degrees), of the polarity of the cell membrane (apical-to-basolateral versus basolateral-to-apical), and of the… CONTINUE READING

From This Paper

Topics from this paper.
15 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 15 extracted citations

Similar Papers

Loading similar papers…