Importance of the noradrenaline-dopamine coupling in the locomotor activating effects of D-amphetamine.

@article{Darracq1998ImportanceOT,
  title={Importance of the noradrenaline-dopamine coupling in the locomotor activating effects of D-amphetamine.},
  author={Laurent Darracq and G{\'e}rard Blanc and Jacques Glowinski and J. P. Tassin},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1998},
  volume={18 7},
  pages={2729-39}
}
The locomotor hyperactivity induced by systemic or local (nucleus accumbens) D-amphetamine injections can be blocked by systemic or local (prefrontal cortex) injections of prazosin, an alpha1-adrenergic antagonist (Blance et al., 1994). Microdialysis studies performed on freely moving animals indicated that prazosin (0.5 mg/kg, i.p.) does not modify the increase in the extracellular dopamine (DA) levels in the nucleus accumbens that are induced by D-amphetamine (2.0 mg/kg, i.p.), but it… CONTINUE READING
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