Importance of the intestine as a site of metformin-stimulated glucose utilization.

@article{Bailey1994ImportanceOT,
  title={Importance of the intestine as a site of metformin-stimulated glucose utilization.},
  author={Clifford J Bailey and K. J. Mynett and Toby Page},
  journal={British journal of pharmacology},
  year={1994},
  volume={112 2},
  pages={671-5}
}
1. The intestine has been implicated as a site of increased glucose utilization by the antihyperglycaemic drug, metformin. This study makes a quantitative assessment of this effect. 2. Glucose utilization by the intestine and hind limb region was determined by arterial-venous glucose difference adjusted for blood flow rate in fasted rats receiving a hyperglycaemic hyperinsulinaemic infusion. 3. Intrajejunal administration of metformin, 250 mg kg-1, increased glucose disposal during the infusion… CONTINUE READING

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