Importance of the character and configuration of residues B24, B25, and B26 in insulin-receptor interactions.

@article{Mirmira1991ImportanceOT,
  title={Importance of the character and configuration of residues B24, B25, and B26 in insulin-receptor interactions.},
  author={Raghavendra G Mirmira and Satoe H Nakagawa and Howard S. Tager},
  journal={The Journal of biological chemistry},
  year={1991},
  volume={266 3},
  pages={1428-36}
}
By use of isolated canine hepatocytes and insulin analogs prepared by trypsin-catalyzed semisynthesis, we have investigated the importance of the aromatic triplet PheB24-PheB25-TyrB26 of the COOH-terminal B-chain domain of insulin in directing the affinity of insulin-receptor interactions. Analysis of the receptor binding potencies of analogs bearing transpositions or replacements (by Tyr, D-Tyr or their corresponding 3,5-diiodo derivatives) in this region demonstrates a wide divergence in the… CONTINUE READING

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