Importance of the amino terminus in secretin family G protein-coupled receptors. Intrinsic photoaffinity labeling establishes initial docking constraints for the calcitonin receptor.

@article{Dong2004ImportanceOT,
  title={Importance of the amino terminus in secretin family G protein-coupled receptors. Intrinsic photoaffinity labeling establishes initial docking constraints for the calcitonin receptor.},
  author={Maoqing Dong and Delia I. Pinon and Richard F. B. Cox and Laurence J. Miller},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 2},
  pages={
          1167-75
        }
}
The calcitonin receptor is a member of the class B family of G protein-coupled receptors, closely related to secretin and parathyroid hormone receptors. Although mechanisms of ligand binding have been directly explored for those receptors, current knowledge of the molecular basis of calcitonin binding to its receptor is based only on receptor mutagenesis. In this work we have utilized the more direct approach of photoaffinity labeling to explore spatial approximations between distinct residues… CONTINUE READING

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