Importance of the MKK6/p38 pathway for interleukin-12-induced STAT4 serine phosphorylation and transcriptional activity.

@article{Visconti2000ImportanceOT,
  title={Importance of the MKK6/p38 pathway for interleukin-12-induced STAT4 serine phosphorylation and transcriptional activity.},
  author={Roberta Visconti and Massimo Gadina and Mario Chiariello and Everett H. Chen and Louis F. Stancato and J. Silvio Gutkind and John J O'Shea},
  journal={Blood},
  year={2000},
  volume={96 5},
  pages={1844-52}
}
Interleukin-12 (IL-12) is a key immunoregulatory cytokine that promotes Th1 differentiation and cell-mediated immune responses. The transcription factor STAT4 (signal transducer and activator of transcription 4) is an important element in mediating IL-12 signals, as evidenced by the fact that STAT4(-/-) mice display impaired responsiveness to IL-12 and deficient Th1 differentiation. STAT4 is inducibly phosphorylated on tyrosine and serine in response to IL-12, but the kinase(s) responsible for… CONTINUE READING

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