Importance of the Intracellular Domain of NR2 Subunits for NMDA Receptor Function In Vivo

@article{Sprengel1998ImportanceOT,
  title={Importance of the Intracellular Domain of NR2 Subunits for NMDA Receptor Function In Vivo},
  author={Rolf Sprengel and B. Such{\'a}nek and Carla Amico and Rossella Brusa and Nail Burnashev and Andrei Rozov and {\O}ivind Hvalby and Vidar R. Jensen and Ole Paulsen and Per Andersen and Jeansok John Kim and Richard F. Thompson and William Y Sun and L C Webster and Seth G. N. Grant and Jens Eilers and Arthur Konnerth and Jianying Li and James O. McNamara and P. H. Seeburg},
  journal={Cell},
  year={1998},
  volume={92},
  pages={279-289}
}

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TLDR
Overexpression of either NR2A or NR2B, but not splice variants of NR1, by transfection caused a significant increase in the total number of functional NMDA receptors and in surface NR1 subunit cluster density in CGCs in primary culture, which solidify the central role of NR2 subunit availability in determining the number of cell surface receptors.
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