Importance of the Dimethylamino Functionality on a Multifunctional Framework for Regulating Metals, Amyloid-β, and Oxidative Stress in Alzheimer's Disease.

@article{Derrick2016ImportanceOT,
  title={Importance of the Dimethylamino Functionality on a Multifunctional Framework for Regulating Metals, Amyloid-β, and Oxidative Stress in Alzheimer's Disease.},
  author={Jeffrey S Derrick and Richard A. Kerr and Kyle J. Korshavn and Michael J McLane and Juhye Kang and Eunju Nam and Ayyalusamy Ramamoorthy and Brandon T Ruotolo and Mi Hee Lim},
  journal={Inorganic chemistry},
  year={2016},
  volume={55 10},
  pages={5000-13}
}
The complex and multifaceted pathology of Alzheimer's disease (AD) continues to present a formidable challenge to the establishment of long-term treatment strategies. Multifunctional compounds able to modulate the reactivities of various pathological features, such as amyloid-β (Aβ) aggregation, metal ion dyshomeostasis, and oxidative stress, have emerged… CONTINUE READING