Importance of the CCR5-CCL5 axis for mucosal Trypanosoma cruzi protection and B cell activation.

@article{Sullivan2011ImportanceOT,
  title={Importance of the CCR5-CCL5 axis for mucosal Trypanosoma cruzi protection and B cell activation.},
  author={Nicole Lea Sullivan and Christopher S. Eickhoff and Xiuli Zhang and Olivia K. Giddings and Thomas E Lane and Daniel F. Hoft},
  journal={Journal of immunology},
  year={2011},
  volume={187 3},
  pages={1358-68}
}
Trypanosoma cruzi is an intracellular parasite and the causative agent of Chagas disease. Previous work has shown that the chemokine receptor CCR5 plays a role in systemic T. cruzi protection. We evaluated the importance of CCR5 and CCL5 for mucosal protection against natural oral and conjunctival T. cruzi challenges. T. cruzi-immune CCR5(-/-) and wild-type C57BL/6 mice were generated by repeated infectious challenges with T. cruzi. CCR5(-/-) and wild-type mice developed equivalent levels of… CONTINUE READING
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